Saturday, December 31, 2011

Triple Analysis: Pancreatic Cancer, Prostate Cancer and Apoptosis

This triple analysis focuses on cancer drug development strategies in both Pancreatic Cancer and Prostate Cancer and by the mechanism/target/effect of Apoptosis. Each of these three individual parts is evaluated according to standardized criteria in a five pillar pipeline drug assessment methodology to compare drug development strategies in oncology. This makes it easy to find and compare analysis not only within one single cancer focus area but also between different areas.

Below is a short synopsis of each part included in this report:

Part I: Pancreatic Cancer

The pancreatic cancer report part comprises defined and up to date development strategies for 213 pancreatic cancer drugs within the portfolio of 137 investigators, from Ceased to Marketed. This report part extensively analyses 171 identified targets of pancreatic cancer drugs, organized into 142 drug target profiles, and assesses them in pancreatic cancer.

This part is based on the following publication:

Portfolio Analytics in the Pancreatic Cancer Pipeline and Portfolio Planning - High Unmet Medical Need but Where to Target?

Part II: Prostate Cancer

The prostate cancer report part comprises defined and up to date development strategies for 346 prostate cancer drugs within the portfolio of 198 investigators, from Ceased to Marketed. This report part extensively analyses 202 identified targets of prostate cancer drugs, organized into 187 drug target strategies, and assesses them in prostate cancer.

This part is based on the following publication:

A Decision Support Tool for Optimizing the Prostate Cancer Pipeline: From Research and Development to Market

Part III: Apoptosis

The apoptotic cancer drug report part comprises defined and up to date development strategies for 234 drugs in oncology within the portfolio of 158 companies world-wide, from Ceased to Marketed. The report extensively analyses their 181 identified drug targets, organized into 157 drug target strategies, and assesses them in 69 cancer indications.

This part is based on the following publication:

Commercializing Apoptotic Drugs in Cancer: The Faster Route to Consider Your Options and Position of Others

The report is written for you to understand and assess the impact of competitor entry and corresponding changes to development strategies for your own portfolio products. It helps teams to maximize molecule value by selecting optimal development plans and manage risk and uncertainty. The report serves as an external commercial advocate for pharmaceutical companies? pipeline and portfolio planning (PPP) in cancer by:

  • Providing you with competitive input to the R&D organization to guide development of early product ideas and ensure efforts are aligned with business objectives
  • Assisting you to make informed decisions in selecting cancer indications that are known to be appropriate for your drug?s properties
  • Analyzing, correlating and integrating valuable data sources in order to provide accurate data for valuation of pipeline, in-licensing and new business opportunities
  • Providing you with commercial analytic support for due diligence on in-licensing and acquisition opportunities
  • Supporting development of integrative molecule, pathway and disease area strategies
  • Integrating knowledge for you to consider the therapeutic target for the highest therapeutic outcome and return on investment
This report provides systems, analytical and strategic support both internally to PPP and to stakeholders across your own organization. The report will also be an important part of creating and implementing a market development plan for cancer drugs to insure that the optimal market conditions exist by the time the products are commercialized.

Source: http://c.moreover.com/click/here.pl?r5684239807&f=378

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Friday, December 30, 2011

Obama Request for $1.2 Trillion Debt Limit Increase Delayed (Michellemalkin)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/181138137?client_source=feed&format=rss

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Avastin May Help Some With Ovarian Cancer: Studies (HealthDay)

WEDNESDAY, Dec. 28 (HealthDay News) -- Two new studies suggest that the drug Avastin may lengthen progression-free survival by about four months for women with ovarian cancer.

What isn't clear yet is whether adding Avastin (bevacizumab) will make a difference in overall survival. One study suggested it would, while the other study didn't find a difference in overall survival between two treatment groups.

"The bottom-line results are a 28 percent reduction in disease progression with patients on continued bevacizumab compared to the standard treatment group. There was a 3.8 month median difference in progression-free survival," said Dr. Robert Burger, author of one of the studies and director of the Women's Cancer Center at Fox Chase Cancer Center in Philadelphia.

"We still have to fine-tune or optimize this sort of new paradigm of treatment. This regimen [chemotherapy plus continued Avastin] could be considered a frontline option for patients with advanced ovarian cancer. However, there are some risks to the treatment, and we haven't shown an impact on overall survival. But, in the European trial, they saw an overall survival benefit," Burger added.

"I think the difficult reality is that these studies are not clear-cut," said Dr. Len Lichtenfeld, deputy chief medical officer for the American Cancer Society. "The improvements in progression are modest and appear to be greater for women who have worse disease. What this ultimately means is that it's absolutely important for doctors treating women with advanced ovarian cancer to read these studies very carefully so they know who may benefit and the risks of treatment, and to counsel their patients very carefully before moving forward with Avastin treatment," Lichtenfeld explained.

"This is not a case where treatment can be initiated in every woman. The benefits for many women are modest at best," he added.

Results of both studies are published in the Dec. 29 issue of the New England Journal of Medicine. The studies were funded by Roche and Genentech (a Roche-owned company). Burger said Genentech played no role in the study design or analysis.

Burger's study included almost 1,900 women with newly diagnosed stage 3 or stage 4 epithelial ovarian cancer. All of the women had undergone surgery to remove as much cancer as possible. They were then randomly assigned to one of three treatment groups: standard treatment including paclitaxel and carboplatin chemotherapy; the Avastin-initiation group that included the standard chemotherapy and Avastin for the second through sixth treatment cycle; and the Avastin maintenance group that included chemotherapy plus Avastin for up to the 22nd treatment cycle.

The average progression-free survival was 10.3 months for the standard group, 11.2 months for the Avastin-initiation group and just over 14 months for the Avastin-maintenance group. There was no difference in overall survival for the three groups.

The European study included more than 1,500 women with varying types of ovarian cancer. Most had epithelial ovarian cancer, but the severity ranged from early-stage disease to stage 4. Seventy percent of the women enrolled in this study had stage 3 or stage 4 cancer.

The women were randomly assigned to receive either standard chemotherapy treatment or chemotherapy plus Avastin for up to 12 cycles of chemotherapy. The dose of Avastin used in this trial was half of what was used in Burger's trial.

Progression-free survival was 20.3 months for the standard group and 21.8 months for the standard therapy plus Avastin. In women who were considered at high risk for progression, the progression-free survival was 14.5 months on standard therapy and 18.1 months with the addition of Avastin. Overall survival in high-risk women was 28.8 months for women on standard chemotherapy and 36.6 months for standard therapy plus Avastin.

High blood pressure is a common side effect of Avastin, but Burger said that in most cases, it can be controlled with blood pressure medication. Another serious side effect associated with Avastin is bowel perforation, which means a hole opens in the bowel wall. This side effect occurred in fewer than 3 percent of women treated, but occurred twice as much in women taking Avastin.

Published reports peg the cost of the drug at somewhere between $4,000 and $9,000 a month, depending on co-pay assistance that's available from Genentech, Avastin's manufacturer. In a previous study, another research group looked at the cost effectiveness of treatment with Avastin in Burger's trial and found the standard treatment arm of the trial cost $2.5 million. Treating the Avastin-initiation group cost $21.4 million and the Avastin-maintenance group cost $78.3 million, according to the study, which was published in the March 7 issue of the Journal of Clinical Oncology. And, most of those costs came directly from the cost of the medication. Those researchers concluded that Avastin was not a cost-effective medication.

"We don't want cost to be a deciding factor, but for many women with ovarian cancer, cost may be a significant factor, and it needs to be weighed in the equation," Lichtenfeld said.

Avastin isn't approved in the United States for the treatment of ovarian cancer, so some insurance companies may balk at paying for it. Plus, the U.S. Food and Drug Administration pulled Avastin's approval for the treatment of metastatic breast cancer in November because the FDA found the risks of the drug outweighed its modest benefits. Avastin is still approved for the treatment of some types of colon, lung, kidney and brain cancer in the United States.

However, the drug was just approved by the European Union for use in ovarian cancer in combination with chemotherapy.

More information

Learn more about ovarian cancer and its treatment from the U.S. National Cancer Institute.

Source: http://us.rd.yahoo.com/dailynews/rss/health/*http%3A//news.yahoo.com/s/hsn/20111229/hl_hsn/avastinmayhelpsomewithovariancancerstudies

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Thursday, December 29, 2011

sluathletics: WOMEN'S HOOPS: Southeastern Closes Non-Conference Road Schedule at Ole Miss http://t.co/5HjkK7Jt #NCAA

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Street fights in Yemen as U.S. considers letting in Saleh (Reuters)

SANAA (Reuters) ? Foes and backers of a plan to ease Yemen's president out of power fought each other with stones and clubs on Tuesday, deepening the country's chaos as Washington considered a request from the leader to fly to the United States.

Youth activists, who have led months of protests against President Ali Abdullah Saleh's 33-year rule, were split on whether he should leave the country - saying it might ease the conflict but could also let him escape justice.

Saleh bowed to months of protests and international pressure by agreeing last month to a deal that granted him immunity from prosecution over his violent crackdown on a popular uprising but saw him hand over power to his deputy.

Far from resolving the crisis, the settlement has caused further tension between groups who opposed the immunity deal, and those who backed it - many of whom have since joined an interim government.

Activists said at least 20 people were injured in the clashes in the capital, Sanaa, between supporters of the Islah party, which backed the immunity deal, and the Houthi movement, a Shi'ite rebel grouping in the north of the country.

Washington and Saudi Arabia, which borders Yemen, both fear continued chaos would allow al Qaeda to build on its already strong presence in the country, which is close to key oil shipping lanes.

After another bout of violence on Saturday - when protesters said Saleh's forces killed nine people who had joined a mass march against the immunity deal - the president vowed to give way to a successor and go to the United States.

U.S. State Department spokesman Mark Toner said on Tuesday Washington was still weighing Saleh's travel request.

"Despite reports to the contrary, the United States is still considering President Saleh's request to enter the United States for the sole purpose of seeking medical treatment," Toner said. "Only at the end of this internal review process will a final visa adjudication be made."

Anti-Saleh protesters said they were in two minds about the possible U.S. trip.

"We are at a loss, between our desire to see Saleh go and avoid Yemen sliding into civil war, and the desire to see him tried for his crimes," said Samia al-Aghbari, a protest leader who was detained briefly after Saturday's violence.

"If he (Saleh) is away and forbidden from being part of the political atmosphere in Yemen, it may help, I see the point of that. But he still has money and weapons in the country and if this doesn't change, nothing will change at any level in Yemen," said activist Hamza Shargabi.

OVERLAPPING CONFLICTS

Any suggestion that Saleh is taking up sanctuary in the United States would be highly controversial among activists and opposition figures who have accused Washington of backing Saleh as an ally in the campaign against al Qaeda.

"He has this relation with the U.S., its war on terror, and torturing people in the name of that war, and putting people in prison," said Shargabi. "Anything can happen in the name of the war on terror."

Hostility against the United States was fanned by Yemeni media reports that Washington's envoy in Sanaa had described Saturday's march as a provocative act, shortly before Saleh's forces cracked down on the protest.

In a statement on Monday, a group of protest organizers demanded Washington recall U.S. Ambassador Gerald Feierstein, whom they called an "advocate and defender of Saleh's ruthless oppression of his people, almost from the start of his assignment in Yemen."

Al Masdar Online, one of the publications which attended a briefing with Feierstein, cited him as saying, in Arabic translation: "Being peaceful isn't just about not carrying weapons. If 2,000 people decided to march on the White House, we wouldn't consider it peaceful and we wouldn't permit it."

The U.S. embassy in Sanaa did not respond to requests for comment on the remarks.

The top "counter-terrorism" official in Washington - which wages a campaign of drone strikes against alleged al Qaeda members in Yemen and assassinated Anwar al-Awlaki, a U.S. citizen, earlier this year - urged Saleh's deputy Abd-Rabbu Mansour Hadi on Sunday to show restraint with protests.

Any successor to Saleh would face overlapping conflicts including renewed separatist sentiment in the south, which fought a civil war with Saleh's north in 1994 after four turbulent years of formal union.

Islamist fighters have seized chunks of territory in the southern Abyan province. Fighting there has forced tens of thousands of people to flee, compounding a humanitarian crisis in a country where about half a million people are displaced.

(Reporting by Mohammed Ghobari; Additional reporting by Laura MacInnis in Honolulu; Writing by Joseph Logan; Editing by Matthew Jones and Christopher Wilson)

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20111228/wl_nm/us_yemen

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Tuesday, December 27, 2011

Oscar voters: Your ballots are in the mail (AP)

LOS ANGELES ? Academy Awards season is officially on. Nominations ballots for the 84th Oscar show have just gone in the mail.

Oscar organizers mailed ballots Tuesday to 5,783 voting members of the Academy of Motion Picture Arts and Sciences.

Ballots are due back Jan. 13, and Oscar nominations will be announced Jan. 24.

The Oscar ceremony is set for Feb. 26, with Billy Crystal returning as host for the first time in eight years.

Among this season's best-picture prospects are the black-and-white silent film "The Artist," the Deep South drama "The Help," George Clooney's family tale "The Descendants" and Steven Spielberg's World War I epic "War Horse."

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/ap/20111227/ap_en_mo/us_oscar_ballots

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Felice Arenas: The Iron Lady Director on Criticism: 'Gird Your Loins'

It seems The Iron Lady director Phyllida Lloyd might have taken notes from fellow Brit Margaret Thatcher when it comes to facing her critics.

At a Los Angeles screening of Lady, which stars Meryl Streep and is based on the first and only female U.K. prime minister, Lloyd shared her thoughts with me about maintaining confidence while receiving early negative reviews for her latest project.

"Just gird your loins and know that [the film] transcends people's preconceptions," she said.

Most of the tomato hurlers, such as former conservative Member of Parliament Norman Tebbit, hadn't even seen the movie but were quick to assess its slant and Streep's highly anticipated presentation, which has already been nominated for and garnered several awards, including a 2011 New York Film Critics Circle Award for Best Actress. She'll certainly receive her 17th Academy Award nomination for the role.

In November, Tebbit wrote in the Daily Telegraph that Thatcher was "never, in my experience, the half-hysterical, over-emotional, over-acting woman portrayed by Meryl Streep."

Mamma Mia!, which also starred Streep, was Lloyd's previous (and first) feature film after she directed the ABBA musical in London's West End and on Broadway. Its 2008 release saw worldwide profits reach more than half a billion dollars -- and it never got swiped at with sharp critical claws. But Lloyd has decidedly found humor in the fact that Lady can't and won't please everybody.

"We bring our own worlds and ourselves to art and when we come to see things. For my niece, this is a movie about female empowerment. It's about a lone woman in a sea of men and what her parents and grandparents lived through," she said. "To my generation... I have friends who have said to me, 'You're putting me in a very difficult position. I've saved up to have the party on the day she dies, how am I going to deal with this? I don't want to see it,' or, you know, 'Get over yourself.' Whatever."

She went on to say that she knew far in advance that a movie centered on the conservative Thatcher would hoist hackles.

"I think I knew a year ago, when I started, very foolishly, looking on the IMDb website for the film and saw people start to go, 'Oh, well, obviously... it's made by a bunch of lefties,'" she explained. "'I mean, there's Meryl, then that other outlaw, Phyllida; they're all left. It's gonna tear her up and rip her down,' and then people coming back and saying, 'no, Hollywood's involved here. It's going to be a total whitewash job.' Then they started tearing each other to pieces about Margaret Thatcher and her policies, and soon the film's left way behind in the discussion."

Streep told the Daily Mail that her own personal politics didn't factor into her performance.

"I still don't agree with a lot of her policies, but I feel she believed in them and that they came from an honest conviction," she said.

The film's title comes from Thatcher's nickname, which the Soviet Union gave her in 1976 in reference to her opposition to communism. Audiences watch her journey to live up to it, starting in mid-1940s Grantham, England, where Margaret Roberts (Alexandra Roach) watches her father, Alfred (Iain Glen), who owns a grocery and is mayor, fire up locals with a protreptic about individual responsibility and business principles in government. His fervor seeps into her just as she heads to Oxford.

For the era, it's rare if not considered preposterous for a woman to covet a government post, but it turns on a young, affable Denis Thatcher (Harry Lloyd), who proposes marriage.

In 1950, she throws her later-criticized blue hat into the political ring (she rarely dons anything but blue). After turning into Mrs. Thatcher (Streep) and having twins Carol and Mark, she works her way to become prime minister in 1979, the same year the Irish National Liberation Army kills Airey Neave (Nicholas Farrell), her confidant and one of the first men to believe in her political aspirations.

Prior to resigning in 1990, she makes enemies out of labor organizations, squares off with Argentina during the Falklands War in 1982, and finds herself and Denis nearly blown to smidir?n? in 1984 when the Provisional Irish Republican Army bombs their hotel in Brighton.

Thatcher's implacable approach to work and life invites contention, and in later years, Denis (Jim Broadbent), who does deeply love his wife, pecks at her lack of attention to him and her children; one scene finds her resolute and ostensibly unaffected as she pulls away in her car from a crying young Carol (Eloise Webb).

While Lady has bursts of energy in flashbacks as it explores a cool Thatcher's power grab and accentuates what a feat it is, given the swells of testosterone in which she wades and the japes she blinks off with sangfroid, it imparts a specific melancholy when depicting her days post prime minister and in old age. It's not easy to watch someone's mighty life end up in mundanity and confusion. It's handled, however, with respectful ministration.

Oftentimes blank-faced or conversing with the ghost of Denis, a pobby Thatcher wanders about in the fuzz that only dementia can swirl with cruel indiscrimination, but with Streep never veering into hapless, hopeless, or hysterical, harried territory, the awkward discomfort that comes from knowing Thatcher is still alive is eased.

Moviegoers experience what's akin to something of a miracle and not unlike a sort of trick: from one eye's wince and a crease that unfolds down to her neck while attempting to understand a grown Carol (Olivia Colman), to catching a toe on a rug and the brief skip that only an old person tries to recover from with another small skip, to, in younger years, pursing doughty lips while listening to disputatious peers, to revealing pleasure after the unveiling of her makeover in a mirror, Streep is Maggie. She doesn't just offer up her voice and mannerisms; she possesses her mental circuitry, and that's what makes her delivery genius.

When I asked Lloyd about the experience of working with Streep a second time, she said she felt "lucky."

"Her investment in a project is so total and her sphere of interest in it is so wide, it starts way before the shoot," she said. "There is a passion and an excitement and an openness, support. I've learned so much from her, and it's not just about acting."

Lloyd, like Thatcher, knows the value of having the right people on her team.

The Iron Lady opens nationwide Friday, Dec. 30.

?

Source: http://www.huffingtonpost.com/felice-arenas/meryl-streep-the-iron-lady_b_1170190.html

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Monday, December 26, 2011

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Fiverr provides 24x7 customer support services to assist you with account issues, orders and any type of problem with the site. Our team of moderators constantly monitor and clean Fiverr, removing poor quality and improper content, spammers and other wrong doers.

Poor quality sellers hurt the community and first and foremost other great sellers. That said, if you are a seller and your account has been restricted, you will be able to withdraw your cleared earnings.

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Islamists kill dozens in Nigeria Christmas bombs (Reuters)

ABUJA (Reuters) ? Islamist militants set off bombs across Nigeria on Christmas Day - three targeting churches including one that killed at least 27 people - raising fears that they are trying to ignite sectarian civil war.

The Boko Haram Islamist sect, which aims to impose sharia law across the country, claimed responsibility for the three church bombs, the second Christmas in a row the group has caused mass carnage with deadly bombings of churches. Security forces also blamed the sect for two other blasts in the north.

St Theresa's Catholic Church in Madala, a satellite town about 40 km (25 miles) from the center of the capital Abuja, was packed when the bomb exploded just outside.

"We were in the church with my family when we heard the explosion. I just ran out," Timothy Onyekwere told Reuters. "Now I don't even know where my children or my wife are. I don't know how many were killed but there were many dead."

Hours after the first bomb, blasts were reported at the Mountain of Fire and Miracles Church in the central, ethnically and religiously mixed town of Jos, and at a church in northern Yobe state at the town of Gadaka. Residents said many were wounded in Gadaka, but there were no immediate further details.

A suicide bomber killed four security officials at the State Security Service in one of the other bombs, which struck the northeastern town of Damaturu, police said. Residents heard two loud explosions and gunfire in the town.

A Reuters reporter at the church near Abuja saw the front roof had been destroyed, as had several houses nearby. Five burnt out cars were still smouldering. There were scenes of chaos, as shocked residents stared at the wreckage in disbelief.

"Mass just ended and people were rushing out of the church and suddenly I heard a loud sound: 'Gbam!' Cars were in flames and bodies littered everywhere," Nnana Nwachukwu told Reuters.

Father Christopher Barde, Assistant priest of the church, said: "The officials who counted told me they have picked up 27 bodies so far."

Police cordoned off the area around the church. Thousands of furious youths set up burning road blocks on the highway from Abuja leading to Nigeria's largely Muslim north.

Police and the military tried to disperse them by firing live rounds into the air with tear gas.

"We are so angry," shouted Kingsley Ukpabi, as a queue of hooting vehicles lined up behind his flaming barrage.

ATTACKS INCREASE

Boko Haram - which in the Hausa language spoken in northern Nigeria means "Western education is sinful" - is loosely modelled on the Taliban movement in Afghanistan.

It has emerged as the biggest security threat in Nigeria, a country of 160 million split evenly between Christians and Muslims, who for the most part live side by side in peace.

Its low level insurgency used to be largely confined to northeastern Nigeria, but it has struck several parts of the north, center and the capital Abuja this year.

Last Christmas Eve, a series of bomb blasts around Jos killed 32 people, and other people died in attacks on two churches in the northeast.

At the church near Abuja, a wounded man whose legs were almost shattered to pieces by the blast was loaded onto a stretcher near an ambulance by security services.

"I'll survive," he said in a hushed voice.

The blast in Jos, a tinderbox of ethnic and sectarian tensions that sometimes sees deadly clashes between Muslims and Christians, was accompanied by a shooting spree by militants, who exchanged fire with local police, said Charles Ezeocha, special taskforce spokesman for Jos.

"We lost one policeman and we have made four arrests. I think we can use them to get more information and work on that," he said. Police found four other explosive devices in Jos, which they deactivated, he added.

President Goodluck Jonathan, a Christian from the south who is struggling to contain the threat of Islamist militancy, called the incidents "unfortunate" but said Boko Haram would "not be (around) forever. It will end one day."

The White House condemned "this senseless violence and tragic loss of life on Christmas Day."

U.N. Secretary-General Ban Ki-moon also condemned the attacks and expressed his condolences "to the people of Nigeria and to the bereaved families."

"The Secretary-General calls once again for an end to all acts of sectarian violence in the country and reiterates his firm conviction that no objective sought can justify this resort to violence," a statement released by his office said.

(Additional reporting by Tife Owolabi and Buhari Bello in Jos, Mike Oboh in Kano and a correspondent in Maiduguri; Writing by Tim Cocks; Editing by Peter Graff)

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/nm/20111226/wl_nm/us_nigeria_blast

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Sunday, December 25, 2011

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Mythmaking begins for NKorea's next leader (AP)

Just before North Korean leader Kim Jong Il died, the skies glowed red above sacred Mount Paektu and the impenetrable sheet of ice at the heart of the mystical volcano cracked with a deafening roar.

At least, that's the official account of the supernatural circumstances preceding Kim's death last Saturday, as relayed by the state-run Korean Central News Agency. The news agency is one of the chief propaganda organs tasked with building up the quasi-religious mystique around the Kim family, which has ruled North Korea since its founding in 1948.

The tools for making the myth have been developed over two generations, dating back to Kim's father, late President Kim Il Sung. But with Kim Jong Il's sudden death and the ascension of his young son Kim Jong Un, North Korea's image artisans will have to do it all at warp speed.

Some of the hallmarks of the mythmaking machine in North Korea:

___

THE BLOODLINE

Founder Kim Il Sung remains North Korea's "eternal president" and lies embalmed at his former presidential palace. Son Kim Jong Il took over after his father's death in 1994 in what was the communist world's first hereditary succession. He's now lying in state at the Kumsusan Memorial Palace.

Kim Jong Il is credited with rewriting the main rules behind North Korea's one-family ideology, called the Ten Principles, after being tapped as his father's successor. His revisions revolved around mythologizing the Kim family and making them central to the nation's identity.

The two late leaders' birthdays are the nation's biggest holidays, and even the calendar year begins with Kim Il Sung's birth year, 1912. This year is Juche 100.

With Kim Jong Un poised to extend the Kim family dynasty into an additional generation, North Korea is quickly building the mythology by emphasizing his bloodline and the Kim family legacy, from its roots as revolutionaries fighting the Japanese to their spiritual role as protectors of the North Korean people.

___

THE LEGENDS

Kim Jong Il's official biography says he was "heaven sent," born in a log cabin in Mount Paektu while his father was fighting the Japanese.

"Wishing him to be the lodestar that would brighten the future of Korea, they hailed him as the Bright Star of Mount Paektu," his biography reads.

Lore has it soldiers spread the news of his birth by inscribing the announcement on trees across the country ? a practice that North Koreans continue today by carving the leaders' messages into rocks and mountainsides.

Soviet records, however, reportedly indicate Kim Jong Il was born a year earlier in Siberia.

The account of his death was just as mythic. His obituary in state media called him the "illustrious commander born of heaven," and on Wednesday, KCNA said a Manchurian crane spotted in the city of Hamhung circled a statue of Kim Il Sung for hours before dropping its head and taking off toward Pyongyang. The crane is a traditional Korean symbol of longevity.

The mythmaking for Kim Jong Un has begun as well, with an editorial in the Rodong Sinmun newspaper calling him "born of heaven." However, details of his birth, and the accompanying legend, have not yet been revealed.

A U.S. official told The Associated Press he is 27 years old, though many observers suspect he will skip a few years and celebrate his 30th birthday in January 2012.

That would make for a mystic convergence of numbers: Kim Jong Il would have turned 70 and Kim Jong Un would turn 30 in the year that Kim Il Sung would have turned 100.

___

THE ICONOGRAPHY

A towering bronze statue of Kim Il Sung, his arm outstretched, lords over the capital city from atop Mansu Hill. In the days since Kim Jong Il's death, mourners have been streaming to the hill to lay flowers at the statue as they typically do for the leaders' birthdays and other major occasions.

Kim Il Sung's smiling face also beams from the face of major buildings, though his portrait at the Grand People's Study House in central Pyongyang was replaced this week by one of Kim Jong Il.

Portraits of the two late leaders feature prominently in every building in North Korea, father and son side by side or standing together in colorful portraits, murals and larger-than-life mosaics interspersed in every village and city across the country.

Some also portray Kim Jong Il's mother, Kim Jong Suk, considered the mother of North Korea.

Similar portraits of the next leader, Kim Jong Un, have not been revealed, though his name has begun appearing in recent months on plaques commemorating visits and offering blessings to all three leaders.

North Koreans are never far from their leaders: Most wear small lapel pins of one of the leader's faces on their left side, "close to our hearts," a government official said.

___

THE PROPAGANDA

Most billboards in North Korea carry slogans, not advertisements, with the leaders' main messages. Recent slogans focus on construction and the economy, such as: "Everything in the name of improving the people's daily lives" ? and tout the goal of building a "strong and prosperous nation." Pillars inscribed with "juche," the national philosophy of self-reliance, line country roads.

North Korea has only one state-run TV channel, which shows cartoons in the late afternoon, the news, and soap operas and films in the evening. Major national announcements ? including the news of the deaths of Kim Il Sung and Kim Jong Il ? are made on state TV.

The Korean Central News Agency (http://www.kcna.kp) is the official news agency of the state while the Rodong Sinmun is the newspaper of the ruling Workers' Party. The leaders' names appear in a larger font than the rest of the text.

___

THE LOOK

Kim Jong Un bears a startling resemblance to Kim Il Sung during his early years as leader. Some North Koreans say they were moved to tears after seeing Kim Jong Un for the first time last year because he so resembled his grandfather.

___

THE NICKNAMES

The Kims ruled North Korea under the title "suryong," or "leader," but are often referred to by other titles as well.

Kim Il Sung, who remains the nation's "eternal President," is also commonly called the "Great Leader."

Kim Jong Il was known as the "Dear Leader" until taking power; during his rule, he was called "Great Comrade," "Supreme Commander" and often "Father."

Kim Jong Un was dubbed "Young General" after being made a four-star general in September 2010. He became "Respected General" in 2011, and was elevated to "Great Successor" after his father's death. North Korean state media this week have referred to him as "Outstanding Leader."

___

THE ARTS

The Arirang "Mass Games" are a stunning spectacle of choreography and synchronicity involving 100,000 dancers tumbling and leaping in unison while students use placards to create a huge, cascading wall of images as a backdrop. The performance also is a key tool for broadcasting the North Korean leadership's main political and economic messages.

In 2010, a new section was added paying homage to ally China that featured somersaulting panda bears.

___

THE SONG

"Tramp, tramp, tramp! The footsteps of our General Kim!"

So go the lyrics of the song "Footsteps," released as the leadership began rolling out the succession campaign for Kim Jong Un ? the first hint to the outside world that an heir had been chosen.

In October, young women in traditional Korean dresses and men in Western-style suits danced to the song, clapping their hands above their heads and stomping around the plaza in front of a huge hammer-and-sickle monument.

Another popular tune is the catchy "Song of CNC," an ode to digital technology, which Kim Jong Un is widely credited with pushing as part of North Korea's economic reform.

While North Koreans learn many of the same traditional Korean songs as children in the South ? such as the popular folk tune "Arirang" ? they have their own patriotic tunes, including "Song of Gen. Kim Jong Il," "Glory to Our Great Party" and "We Live in the Embrace of the Leader."

___

Follow Jean H. Lee on Twitter at twitter.com/newsjean and photographer David Guttenfelder at twitter.com/dguttenfelder.

Source: http://us.rd.yahoo.com/dailynews/rss/nkorea/*http%3A//news.yahoo.com/s/ap/20111222/ap_on_re_as/as_kim_jong_il_making_the_myth

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Saturday, December 24, 2011

PFT: If Giants win, Eagles-'Boys means nothing

New York Giants v Dallas CowboysGetty Images

Since 2006, the league has been using a flexible schedule on Sunday nights to ensure that a competitive and interesting game always will occupy the prime-time slot.? In most weeks of flex scheduling, the decision comes at least 12 days before the games are played.? For Week 17, the decision usually is made after the full Week 16 slate of games has been played, and it?s unveiled no later than six days before the final Sunday.

Unlike all other weeks of flexible scheduling, no game has even tentatively been placed in the 8:20 p.m. ET time slot.? Instead, all games have a 1:00 p.m. or 12:00 p.m. local time kickoff (for three games due to start at 4:15 p.m. ET, it?s a 1:15 p.m. local start), and the NFL will choose one of those 16 games to be the final act of the regular season, since no Monday night game is played in Week 17.

The goal every year becomes finding a game with clear playoff implications that can?t be resolved based on the outcomes of games played earlier in the day.? And that?s not always an easy thing to do.

Last year, only the Seahawks and Rams provided a clear-cut pre-playoff game, with the winner capturing the NFC West and the loser being bounced from the postseason field ? regardless of the final score of any other game played that day.

This year, a game with obvious playoff implications regardless of what happens elsewhere could be hard to find.? Here?s a quick glance at the potential relevance of each game.

Redskins at Eagles:? Since Philly?s shot at winning the NFC East would hinge (if it survives Week 16) on the Giants beating the Cowboys, this game could be irrelevant.

Lions at Packers:? Green Bay?s clinching of the top seed, if they don?t have it after this weekend, would come if the 49ers lose to the Rams in Week 17.? Also, losses by other teams would deliver a Detroit playoff berth, if Detroit doesn?t clinch it this weekend.? Then again, whether the Packers have the No. 1 or No. 2 seed really isn?t that big of a deal in the grander scheme of things.

Ravens at Bengals:? Depending on the Week 16 games, this game could have implications for the AFC North title, the No. 2 seed, and the final wild-card berth.? But those implications could become irrelevant based on the other games played in Week 17, which makes this game less attractive for prime time.

Jets at Dolphins:? Again, Week 16 will provide more clarity.? With the Jets and Bengals each 8-6, however, it?s unlikely that the Jets will have a clear win-and-in, lose-and-leave scenario that would apply regardless of what the Bengals do against the Ravens.

Panthers at Saints:? New Orleans could be playing for the No. 2 seed and/or the NFC South crown, but those could be decided via losses earlier in the day by the Falcons or the 49ers.

Buccaneers at Falcons:? If the Falcons still haven?t clinched a playoff berth after Monday night, losses by others could deliver the spot earlier in the day on January 1.

49ers at Rams:? San Fran is jockeying for the No. 2 or No. 1 seed, which if still relevant after Week 16 could be completely irrelevant before 8:20 p.m. ET in Week 17.

Bills at Patriots:? The Pats are playing for the top seed, but the outcomes of the Steelers and Ravens games could strip this one of any remaining relevance.

Colts at Jaguars:? It?s very highly unlikely that the league would want to showcase the ?Suck for Luck? finale.? In 2008, for example, the NFL had no interest in televising in prime time the Lions? date with 0-16 destiny.

Titans at Texans:? Houston has an outside shot at a bye, but it will depend on the Steelers and Ravens games from earlier in the day.

Bears at Vikings:? This one would be attractive in prime time only for anyone who stayed up too late and drank too much on New Year?s Eve and doesn?t want to miss anything important.

Cowboys at Giants:? If the Giants beat the Jets on Saturday, the NFC East likely will hinge on this game, with the loser most likely being done.? It could be one of the best candidates for the prime-time slot, based on the clarity provided by Week 16.

Steelers at Browns:? Um, no.

Chiefs at Broncos:? The Broncos definitely will win the AFC West by beating the Chiefs.? The only problem is that the Broncos could nail it down before 8:20 p.m. ET on January 1, making the game irrelevant.

Seahawks at Cardinals:? It could be one of the best games of the day.? But it very likely will have zero relevance to the postseason.

Chargers at Raiders:? With the Broncos able to win the division by beating the Chiefs, there?s no reason to hold this one ? unless somehow it would present a clear-cut win-and-in for a wild-card berth for one of the two teams.

And so, for now, it appears that the best candidates are Cowboys-Giants and Chiefs-Broncos.? We?ll know more by Monday night.

In the end, there?s a chance that the NFL will simply have to assume a calculated risk that one or more of the outcomes earlier in the day will screw up the New Year?s Night party on NBC.

Source: http://profootballtalk.nbcsports.com/2011/12/22/if-giants-beat-jets-eagles-cowboys-becomes-meaningless/related/

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Nokia Lumia 800 infiltrates Washington, succumbs to FCC teardown

It's a rite of passage for any stateside-bound communications device, and now Nokia's darling Windows Phone handset has arrived at FCC HQ to lay disrobed alongside the agency's imposing L-square ruler. The Lumia 800 has been available through carriers in other countries since shortly after its Nokia World launch, but it has yet to land in the US with a carrier subsidy. It's not clear exactly where the shiny slab is headed after its mandatory pit-stop near the nation's capital, though with no reports of 1700 MHz AWS on board, it's safe to say that this iteration won't be joining its Lumia 710 sibling over at T-Mobile.

Continue reading Nokia Lumia 800 infiltrates Washington, succumbs to FCC teardown

Nokia Lumia 800 infiltrates Washington, succumbs to FCC teardown originally appeared on Engadget on Wed, 21 Dec 2011 15:54:00 EDT. Please see our terms for use of feeds.

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Friday, December 23, 2011

Government plans olive oil, sugar beet subsidies

BEIRUT: The government intends to launch olive oil and sugar beet subsidies, said Agriculture Minister Hussein Hajj Hasan.

Hajj Hasan said his ministry had prepared the sugar beet subsidies draft decree and intended to pass it on to Prime Minister Najib Mikati and other concerned ministers for further examining.

Olive farmers rejected Monday a Cabinet decision last week to buy 50,000 20-liter canisters of olive oil.

The quantity, designated for Lebanese Army consumption, is intended to support farmers who have been saying they are unable to market more than 200,000 canisters of 2011 produced olive oil. ?

Source: http://www.dailystar.com.lb/Business/Lebanon/2011/Dec-22/157621-government-plans-olive-oil-sugar-beet-subsidies.ashx

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Flyers coach Laviolette shoves Stars' Ott in tunnel scuffle

Philadelphia Flyers coach Peter Laviolette exchanged words with Dallas Stars tough guy Steve Ott, and then gave Ott a shove, after the first period of Wednesday's game in Dallas.

Ott appeared to block the coach?s path back toward the dressing room as the teams were leaving the ice. Laviolette responded by trying to move the Stars forward out of his way.

After the game, Ott said the confrontation was all about allowing the Stars to exit first as a courtesy in their own building.

"It's disrespect of our building, just let our team off, it's not a big deal," Ott said. "He obviously thought that he has a higher power than everybody else and a little bit more arrogance. Of all the coaches in the whole NHL, that's probably the first time I've seen that.

"I would never do that if I was in Philadelphia in their building and had to walk through their lineup. Just let us go and show a little respect, that's all."

Laviolette refused to comment on the incident after the game, instead wanting to focus on how the Flyers' win put the team back atop the Eastern Conference standings.

"Unfortunately, the Blackhawks won," Laviolette said, meaning that the Flyers would not be atop the NHL standings, just the East. "We should probably keep it about the game because it was such a big win for our team

Ott continued to get chirpy in the second period with the Flyers? bench. Marc-Andre Bourdon dropped his gloves to try to fight Ott, but Ott never engaged him.

"I was trying to stand up for my partners," said Bourdon. "If he's chirping at others, just fight me but then Morrow got in there. He [Ott] turned around first... He's just a [bleep]."

At the end of the second period, the Flyers were instructed by officials to leave the ice through the Zamboni door at the far end of the rink.

The Flyers won the game, 4-1.

The NHL's Director of Hockey Operations Colin Campbell will get to make the call of whether or not Laviolette was in the wrong, according to Darren Dreger of TSN.ca.

Source: http://aol.sportingnews.com/nhl/story/2011-12-21/flyers-coach-laviolette-shoves-stars-ott-in-tunnel-scuffle

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Thursday, December 22, 2011

Lifeboats found empty in search for Russian crew (AP)

MOSCOW ? Four lifeboats and an inflatable raft were found empty in frigid waters near where an oil rig sank off Russia's eastern coast, rescuers said Tuesday, as hopes faded of rescuing the 39 men still missing.

The search continued for a third day, with an airplane, two helicopters and three ships scouring the Sea of Okhotsk where the rig capsized and sank on Sunday.

Of the 67 men aboard, 14 were rescued from the icy water. The Emergencies Ministry said Tuesday that 11 bodies have been recovered and three objects believed to be bodies have been spotted but not yet retrieved. There was no sign of the others.

The State Sea Rescue Coordination Center said lifeboats that had been spotted earlier turned out to be empty, though one of the boats had its emergency lights on.

The Kolskaya floating platform was being towed back to a Sakhalin Island port in a fierce storm when a strong wave broke some of its equipment and portholes, and it capsized in the choppy water.

The survivors suffered from exposure and bruising, but doctors said they were most in need of psychological treatment after the trauma.

Ivan Mishnev, one of the hospitalized survivors, said he swam away from the platform and saw it capsize. "I was afraid I'd be sucked down into the crater that formed when it sank," he said in an interview broadcast on NTV television.

The rescue operation began only two hours after the rig sent an SOS calling for help and investigators were looking into whether more could have been done to save the crew, said Alexander Dyomin, a transport investigator.

They also were investigating the decision to transport the platform across the open sea during winter, he said on state television.

Relatives of the crew have insisted they were forced to move the platform against their better judgment. The Kolskaya's captain, Alexander Kozlov, opposed the decision but his objections were ignored, according to his wife, Lyudmila. She was quoted by the newspaper Komsomolskaya Pravda as saying he had called home last week and said he feared the rig would topple in a storm.

Most of the crew were from the northwestern city of Murmansk, where a day of mourning was observed Tuesday.

The platform ? 70 meters (226 feet) long and 80 meters (262 feet) wide ? was built in Finland in 1985. It was used recently by the Russian energy giant Gazprom.

Source: http://us.rd.yahoo.com/dailynews/rss/russia/*http%3A//news.yahoo.com/s/ap/20111220/ap_on_re_eu/eu_russia_oil_platform

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Sunday, December 18, 2011

#SciAmBlogs Friday - soccer, X-men, geoengineering and more...


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Have a great weekend!

- Glendon Mellow ? Atmosphere and Action: Interview with illustrator Tyler Jacobson

?

- Maille Lyons ? How to Answer the 5 Most Common Questions from a Science Fair Judge

?

- S.E. Gould ? Bacteria that could pass as X-men: part 2

?

- Melissa C. Lott ? Geoengineering? The Earth Doesn?t Need to Change ? We Do

?

- Scicurious ? Friday Weird Science: Ostrich erections always go lymph.

?

- Larry Greenemeier ? How to Find Meaning in a Maelstrom of Data

?

- Katherine Harmon ? Malaria Deaths Falling Slowly, WHO Report Says

?

- Gary Stix ? Pel? and Maradona Help Us Understand How Memory Works

?

=======================

Conversations on our articles and blog posts often continue on our Facebook page ? ?Like? it and join in the discussion. You can also put our official Google Plus page in your circles.

You should follow the Blog Network on Twitter ? the official account is @sciamblogs and the List of all the bloggers is @sciamblogs/sciambloggers.

Bora ZivkovicAbout the Author: Bora Zivkovic is the Blog Editor at Scientific American, chronobiologist, biology teacher, organizer of ScienceOnline conferences and editor of Open Laboratory anthologies of best science writing on the Web. Follow on Twitter @boraz.

The views expressed are those of the author and are not necessarily those of Scientific American.

Source: http://rss.sciam.com/click.phdo?i=6f2be0a774da56ffc423d489f498335c

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Simon Cowell: Paula Abul & I Almost Had Sex

Apparently, we weren't just imagining all that potent sexual tension between Simon Cowell and Paula Abdul. Cowell admits that he did indeed consider hooking up with his X Factor co-judge during their days together on American Idol.

Source: http://www.ivillage.com/simon-cowell-paula-abul-almost-had-sex/1-a-411279?dst=iv%3AiVillage%3Asimon-cowell-paula-abul-almost-had-sex-411279

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Saturday, December 17, 2011

Grand Theft Auto III now available on Android

Grand Theft Auto III

Sex, guns, drugs, violence -- and that's just in the splash screen. Yes, folks, Grand Theft Auto III is now available on Android as part of Rockstar Games' 10th anniverssary celebration of the game. It's been optimized for touchscreens. But if you've got an Android device that suppports USB controllers, you can rock one of them as well. (And Rockstar's promising support soon for the Galaxy Nexus.

It'll cost you $4.99 and a few hours of your life. We've got download links after the break.

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/ki9xFoZRBxs/story01.htm

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BP settles with maker of failed blowout preventer (AP)

NEW ORLEANS ? Cameron International, maker of the Deepwater Horizon blowout preventer that failed to stop last year's massive oil spill in the Gulf of Mexico, has agreed to pay $250 million to BP under a legal settlement, BP said Friday.

BP said it was "in their mutual best interests, and the agreement is not an admission of liability by either party." The companies are dropping all claims against one another, they said.

The settlement comes in advance of a federal trial over the catastrophic Gulf oil spill. The non-jury trial is slated to begin in February and determine fault in the April 20, 2010, explosion and subsequent oil spill off the Louisiana coast of more than 200 million gallons of oil.

Oil and gas analysts said they saw Friday's settlement as setting the stage for more out-of-court agreements. At this point, Halliburton Corp., which supplied the cement to seal the blown-out well, and Transocean Ltd., the drilling company, have not settled with BP. The federal government, individual Gulf states and many other plaintiffs also have not settled.

For the companies involved, and government entities, "it's better to make peace than make war," said Fadel Gheit, managing director of Oppenheimer & Co., a Wall Street investment bank. He studies the oil and gas markets and follows BP closely.

He said he would expect all the parties ? including the federal government ? to seek to settle the Deepwater Horizon case before it goes to trial. He called court "the last resort."

"The strategy right now is settle, settle, settle," he said. "I would say that once the companies settle, the government will be under increasing pressure to settle."

Phil Weiss, a senior oil and gas analyst with the Argus Research Co. in New York, agreed and said he expected more settlement announcements. "I think it's in the interest of all these parties to settle."

For now, the settlement with Cameron does not end the legal fighting over the blowout of the Macondo well, which was owned by London-based BP and two partners, MOEX and Anadarko. BP has already settled claims with those two companies and a third company, Weatherford, the maker of a part used in the well.

"Today's settlement allows BP and Cameron to put our legal issues behind us and move forward to improve safety in the drilling industry," said Bob Dudley, BP group chief executive. "Unfortunately, other companies persist in refusing to accept responsibility for their roles in the accident and for contributing to restoration efforts," Dudley said in a swipe at Halliburton and Transocean.

The blowout preventer is the last line of defense in an oil well and is supposed to shear the well and cap it. But the device placed over the Macondo well failed to work properly and choke off the out-of-control spill. Government investigators have charged that the device had a design flaw and was not maintained properly. A bent pipe also prevented it from working, investigators found.

After the spill, the large contraption was lifted from the sea floor of the Gulf and transported to a NASA facility in New Orleans where engineers pored over it and conducted tests to determine what went wrong with it.

Probes of the Deepwater Horizon explosion by the federal government and independent scientists and engineers have found all three companies were at fault for a series of decisions and actions that led to the Macondo well blowout, the nation's largest offshore oil spill.

BP is engaged in an intense legal fight with Halliburton and Transocean. Earlier this month, BP went so far as to accuse Halliburton employees of covering up damaging evidence about a cement mixture Halliburton used in drilling the well.

BP said it would use the $250 million from Cameron to pay for the cost of cleaning up from the spill and paying individual damage claims by people, businesses and government entities hurt by the spill. BP said it has spent about $7.5 billion so far of those claims. But the British company faces billions of dollars in additional damages and fines.

Under the agreement, BP said Houston-based Cameron is no longer responsible for any additional cleanup costs related to the spill. But BP said the agreement does not cover civil, criminal and administrative fines and other penalties that might arise out of the court proceedings.

Jack Moore, chairman and CEO Cameron, said the agreement with BP "removes uncertainty facing Cameron" as litigation intensifies over the Deepwater Horizon explosion.

"This eliminates all significant exposure to historical and future claims related to this incident," Moore said.

Moore said Cameron does not expect to have to pay much for possible court fines and penalties. "We do not consider these items to represent a significant risk to Cameron," he said.

Cameron said its insurers were expected to fund at least $170 million of the $250 million payment the company agreed to make to BP.

BP and Cameron also pledged to "improve safety in the drilling industry" and do more to improve blowout preventers.

So far, BP has spent about $25 billion on the Deepwater Horizon disaster and has said it expects the final bill to be about $40 billion, Gheit said. BP has received about $5 billion from the companies it has settled with, he said.

Source: http://us.rd.yahoo.com/dailynews/rss/mexico/*http%3A//news.yahoo.com/s/ap/20111216/ap_on_re_us/us_gulf_oil_spill_settlement

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Friday, December 16, 2011

FOR KIDS: Eastern quakes can trigger big shakes

Scientists study the widespread impacts of tremors east of the Rockies

Web edition : Wednesday, December 14th, 2011

The most dangerous type of natural disaster, and also the most unpredictable, is the earthquake.?In the first week of November 2011, people in central Oklahoma experienced more than two dozen earthquakes. The largest, a magnitude 5.6 quake, shook thousands of fans in a college football stadium, caused cracks in a few buildings and rattled the nerves of many people who had never felt a quake before. Oklahoma is not an area of the country famous for its quakes.

Although less expected than quakes in California and Alaska, these ?mid-plate? tremors can do substantial damage. Some of the biggest known examples, centered over Missouri,?rattled the eastern half of the United States two centuries ago. Today, scientists are still puzzling over what triggered past quakes in these places?? and when similar ones might strike again.

Visit the new?Science News for Kids?website?and read the full story:?Eastern quakes can trigger big shakes


Found in: Science News For Kids

Source: http://www.sciencenews.org/view/generic/id/336842/title/FOR_KIDS_Eastern_quakes_can_trigger_big_shakes

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